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The active ingredient Baclofen is one of the most important drugs in increased skeletal muscle tension (spasticity). It was made in 1962 for the first time and is now included in many medications. He is generally well tolerated, can lead to fatigue and gastrointestinal symptoms in rare cases, however. Children and pregnant women should take Baclofen only after consultation with the doctor. Here you can read everything about Baclofen.
How Baclofen acts
The human skeletal muscle is activated or inhibited by certain chemical messengers (neurotransmitters). Normally, these messengers are released according to the external circumstances. A specific chemical messenger, called gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (brain and spinal cord). GABA provides inter alia for sleep and muscle relaxation and suppresses muscle spasms.
In diseases or injuries of the nervous system that controlled balance is disturbed and GABA sometimes not sufficiently effective. The result: The nervous system is hyperexcitable, and there may be multiple sclerosis and spasticity (unnatural, resistant strain of the muscles)
The active ingredient Baclofen engages a particular docking site of GABA at (GABA B receptor) and mimics the effect. This receptor is specifically responsible for muscle tension. So there is a relaxation of the affected muscles, and spasticity is alleviated.
Up, degradation and excretion of Baclofen
The active ingredient Baclofen is rapidly and almost completely absorbed from the intestine into the blood. However, the amount of Baclofen, reaches the actual site of action (central nervous system), relatively low. For very severe spasticity of the drug is therefore (fluid in the brain) is introduced directly into the cerebrospinal fluid, thus high concentrations can be achieved at the site.
The active substance is excreted unchanged by the kidneys.Lioresal (Baclofen) 10mg
When will Baclofen used?
.Among the areas of application (indications) of Baclofen include:
.spasticity of the skeletal muscles through
.spasticity of skeletal muscle due to injury or disease of the spinal cord
.spasticity of skeletal muscle due to injury or dysfunction of the brain
How Baclofen is used
Normally occupied Baclofen in the form of tablets. For better tolerability of the drug should be taken with a meal. In case of severe symptoms Baclofen can also be introduced as an infusion directly into the cerebrospinal fluid of the brain.
The Baclofen dosage in adults is a maximum of 75 milligrams daily (rarely up to 120 milligrams). This amount should be achieved by slowly increasing the dose, whereby an individual dose must be found for each treated. It usually starts with five milligrams three times a day and then increasing the dose until the symptoms have improved significantly.
Children and young people receive a reduced dose.
Normally it is in the treatment with the drug Baclofen to a long-term treatment. The discontinuation of the drug must be “tapered off”. This means that you have to reduce the dose over a period of about two to three weeks gradually.
What are the side effects Baclofen?
Especially at the beginning of treatment may cause side effects such as Baclofen gastrointestinal problems, fatigue or drowsiness (daytime).
Sometimes, ie in less than one percent of those treated, it may lead to, among other things, and tremors.
What should be considered when taking Baclofen?
The drug should be used with caution when the patient is suffering from renal impairment, severe mental illness or acute confusion states. This is especially true if a poisoning with alcohol or sleeping pills is present.
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