Buy Folotyn 20mg/1ml online
Buy Folotyn 20mg/1ml, PRALATREXATE (pral a TREX ate) is a chemotherapy drug. This medicine affects cells that are rapidly growing, such as cancer cells. It is used to treat lymphoma, a certain type of cancer.
Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
What are the indications and usage?
FOLOTYN is a folate analogue metabolic inhibitor indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). This indication is based on overall response rate. Clinical benefit such as improvement in progression-free survival or overall survival has not been demonstrated.
Mechanism of Action
Buy Folotyn 20mg/1ml,The selectivity of pralatrexate for cancer cells is based upon the observation that cancer cells generally have an overexpression of reduced folate carrier protein-1 (RTC-1) compared to normal somatic cells. This carrier protein allows the entrance of pralatrexate into the cell. Upon entering the cell, folypolyglutamate synthase FPGS catalyzes the polyglutamination of pralatrexate so that it is retained inside the cell. Once inside, pralatrexate competitively inhibits dihydrofolate reductase (DHFR) and thymidylate synthase. Subsequent depletion of thymidine monophosphate (TMP) occurs so that the cancer cell is unable to synthesize DNA and RNA. As a result, the cancer cell cannot proliferate and is forced to undergo apoptosis. Pralatrexate is more effective against cells that are actively dividing. Folotyn is so good for the elimination of cancer cells in the blood .
How supplied/storage and handling?
FOLOTYN is available in single-use clear glass vials containing pralatrexate at a concentration of 20 mg/mL as a preservative-free, sterile, clear yellow solution individually packaged for intravenous use.
Vials must be stored refrigerated at 2-8Â°C (36-46Â°F) ( see Â USP Controlled Cold Temperature) in original carton to protect from light.
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