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5F-AKB-48, or 5F-APINACA is a synthetic cannabinoid drug containing a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22.And the indazole is substituted at R3 with a carboxamide group. This group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. 5F-AKB-48 is an analog of STS-135 in which the core indole structure is substituted with an indazole base.
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